Probably not a problem for everyone but it was a problem I was running into where my meds weren’t being as effective towards the bottom of the bottle and then would work great after a refill.

My meds are supposed to be stored between 67F and 77F and my apartment has been routinely getting to around 85F for days (and weeks) at a time and by the time I was getting close to the bottom of the bottle it wasn’t really working that well for me.

So I took one of those can fridges and added some temperature control to it to automatically keep it in the temperature range I need and also added a large bag of dessicant in there to keep the humidity low as those little can fridges suck up moisture something fierce.

So basically make sure your meds are stored properly or you’ll probably have some additional issues that you really don’t need.

    • medgremlin@midwest.socialEnglish
      0·
      3 months ago

      I’m repeating my reply to someone else in the thread so hopefully more people can see it:

      I looked it up and read through the NIH paper that did a review of available information about it. It’s essentially a recreational drug that can be formed in your body when you take methylphenidate and alcohol at the same time.

      I will put out this caution though: there were a lot of reports of bad trips, worsened focus/cognition, dangerous side effects like increased heart rate and body temperature, and there was a very high rate of addictive responses. So it may sound like fun, but you’re running the risk of causing yourself a lot of problems and using Ethylphenidate (or methylphenidate plus alcohol) may make your regular ADHD meds less effective and lead into addiction problems.

      TL;DR: This is a dangerous, bad idea and as a medical student with a decent understanding of pharmacology, I do NOT recommend doing this.

      • Biezelbob@programming.devEnglish
        0·
        3 months ago

        Pharmacokinetics

        Ethylphenidate metabolizes into methylphenidate and ritalinic acid.[4]

        Tiny amounts of ethylphenidate can be formed in vivo when ethanol and methylphenidate are coingested, via hepatic transesterification.[5] Ethylphenidate formation appears to be more common when large quantities of methylphenidate and alcohol are consumed at the same time, such as in non-medical use or overdose scenarios.[6] However, the transesterfication process of methylphenidate to ethylphenidate, as tested in mice liver, was dominant in the inactive (−)-enantiomer but showed a prolonged and increased maximal plasma concentration of the active (+)-enantiomer of methylphenidate.[7] Additionally, only a small percentage of the consumed methylphenidate is converted to ethylphenidate.[5]

          • medgremlin@midwest.socialEnglish
            0·
            3 months ago

            I looked it up and read through the NIH paper that did a review of available information about it. It’s essentially a recreational drug that can be formed in your body when you take methylphenidate and alcohol at the same time.

            I will put out this caution though: there were a lot of reports of bad trips, worsened focus/cognition, dangerous side effects like increased heart rate and body temperature, and there was a very high rate of addictive responses. So it may sound like fun, but you’re running the risk of causing yourself a lot of problems and using Ethylphenidate (or methylphenidate plus alcohol) may make your regular ADHD meds less effective and lead into addiction problems.