Researchers at Harvard Medical School and Brigham and Women's Hospital designed an ingestible capsule that delivers liquid mRNA to the intestines, producing gene expression and reducing inflammation in rats.
RNACap uses pH-sensitive coatings and pressure-triggered release membranes to remain intact in the stomach. Contents are released in the intestine in response to neutral pH and peristalsis.
Nanoparticles were formulated using G0-C14, PLGA, and PEG-lipid components for mucus penetration and endosomal escape. A 5% DMPE-PEG formulation showed optimal transfection in vitro.
no prob. If I read the article I usually try to paste what I feel is the most relevant bit and once in awhile I will do the whole thing or if its too long I will add a comment encouraging people to read the article if its good enough.
RNACap uses pH-sensitive coatings and pressure-triggered release membranes to remain intact in the stomach. Contents are released in the intestine in response to neutral pH and peristalsis.
Nanoparticles were formulated using G0-C14, PLGA, and PEG-lipid components for mucus penetration and endosomal escape. A 5% DMPE-PEG formulation showed optimal transfection in vitro.
oh man. as a needlephobe. please. please. please.
I just saw a similar article about using this delivery method for insulin. I’m just some plebeian but it’s all very interesting!
Thanks for the summary!
no prob. If I read the article I usually try to paste what I feel is the most relevant bit and once in awhile I will do the whole thing or if its too long I will add a comment encouraging people to read the article if its good enough.